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This is often referred to as “Morton’s neuroma”. It is a condition where one of the small nerves between the toes becomes irritated or thickened. This is a nerve that passes between the bones of your foot. It most commonly affects the nerve between the third and fourth toes, although it can also occur between the second and third toes. It is most common in people aged 40–60 and is more common in women than men.

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Tight or narrow footwear can increase pressure on the nerve and make symptoms worse. Repetitive high-impact activities, such as running or jumping, may also contribute.
The main symptoms of a intermetatarsal neuroma are:
Try to keep moving while temporarily reducing activities that significantly increase your pain. Completely avoiding activity for long periods is usually not helpful. If prolonged walking, running or standing aggravates your symptoms, reducing these activities for a short period may help settle a flare-up before gradually returning to normal activity.
Over-the-counter medicines: Over-the-counter pain relief may help you stay active. Always follow the advice provided with the medicine.
Topical creams: Some people find topical creams or gels helpful for short-term relief of pain and stiffness.
It is important to check whether you can take these medicines. If you are unsure whether you can take these medicines, speak to a pharmacist or another healthcare professional.
Choose supportive shoes with a wide toe box and avoid tight, narrow or high-heeled footwear where possible.
Some patients find insoles with a metatarsal dome (pad) helpful. These can be purchased over the counter or provided by podiatrists or orthotists.
If you are carrying extra weight, even a modest amount of weight loss can reduce the load through the foot and ankle and improve symptoms. You can calculate your BMI using the NHS BMI calculator.
If your symptoms are not improving, or you feel you need more support, you can refer yourself to the podiatry service. They can assess your symptoms, develop a treatment plan and refer you to other services if appropriate.
Injections may reduce severe inflammation and pain for a period. The physiotherapy service can organise foot and ankle injections for appropriate patients. It is not an appropriate option for everyone.
Most people improve with simple treatments such as changing footwear, using insoles where appropriate and gradually returning to activity. Surgery is only needed for a small number of people whose symptoms do not improve with conservative treatment.
If you have diabetes and develop foot pain, discuss this with your GP or diabetes team. People with diabetes are at increased risk of developing foot problems and may need assessment sooner. Your GP or diabetes team can ensure you are receiving the most appropriate treatment.
Symptoms of a intermetatarsal neuroma are influenced by several factors, including footwear, repetitive loading of the foot, weight and overall health. Wearing supportive footwear with a wide toe box, remaining active within your limits, and addressing lifestyle factors can help reduce symptoms and improve function. More support with health and lifestyle factors can be found on our Your Musculoskeletal Health webpage.
When to seek further advice
Some symptoms require urgent medical assessment rather than physiotherapy or podiatry. Please seek urgent medical advice if you have any of the following:
If any of the above apply to you, contact NHS 111 for advice or attend your nearest Emergency Department if your symptoms are severe.